Pharmacological studies of liver damaging substance, ethionine
نویسندگان
چکیده
منابع مشابه
Studies on ethionine. III. Incorporation of ethionine into rat proteins.
Since ethionine was shown to have an inhibitory effect on the uptake of methionine into the liver proteins of rats and mice in viva (l), we have been led to speculate further on the relationship between this amino acid and its analogue in protein metabolism. Although the action of ethionine was assumed to be due to some form of competitive inhibition, alternatively it appeared possible that the...
متن کاملStudies of the ethylation of rat liver transfer ribonucleic acid after administration of L-ethionine.
1. The ethylated nucleosides present in tRNA isolated from the livers of rats treated with 0.5g of l-ethionine/kg body wt. were investigated. Evidence that this tRNA contained N(2)-ethylguanine, N(2)N(2)-diethylguanine, N(2)-ethyl-N(2)-methylguanine, 7-ethylguanine, two ethylated pyrimidines and ethylated ribose groups was obtained. 2. Ethylation of bacterial tRNA was catalysed by extracts cont...
متن کاملStudies on ethionine. V. Sex difference in incorporation in vivo of ethionine into rat proteins.
Among the various effects of administering ethionine to rats, the induction of a fatty liver was shown to occur in female but not in male rats (2, 3). A similar sex difference was observed in the ethionine inhibition of hepatic protein synthesis (4). The sex difference in the ethionine-induced fatty liver has been attributed to the presence of androgens in the male, since orchidectomy makes the...
متن کاملThe inhibition of liver ribonucleic acid synthesis by ethionine.
The administration of DL-ethionine to female rats inhibits liver ribonucleic acid synthesis up to 90 to 95%. The inhibition of RNA synthesis follows in time the decrease in adenosine triphosphate concentration and precedes the inhibition of protein synthesis. The degree of inhibition of RNA synthesis is a function of the dose of ethionine. The curve for this inhibition parallels closely the cur...
متن کاملEffects of DL-ethionine on mouse liver tRNA base composition.
Treatment of mice with DL-ethionine and adenine causes a reduction of all methylated bases of liver tRNA. This effect is dose-dependent and specific for the methylated bases. Individual methylated components are affected to different extents, m22G being most sensitive to inhibition.
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1967
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.63.572